The game is set up much like other True20 books. You have your three archetypes/characters (Adept, Expert, Warrior) and a host of new feats and powers to choose from. Some are campaign-specific but almost all could be used anywhere else. In fact there is enough here that the main feature of MvK is readily apparent; you don't have to do games about fighting giant monsters all the time. Now of course the main plot and thrust of this game is fighting giant monsters, but I can easily see some adventures of exploring monster islands, contests between cocky pilots, mad scientists, children with newly awakened psychic powers.
When I first read this game my thoughts went first to Godzilla, but you can do Akira here as well and any number of other "Neo Tokyo" genres. Plus it is compatible with a host of True20 books I already have, so adding cyberpunk, horror or even comedy is easy.
If you don't like the campaign background you can leave it, but I think you would be missing out on something really fun if you do.
This might in fact be my favorite True20 setting.