Okay, I'm in a gripey mood. So this will be full of gripes. However, don't let it sway you too far wrong, this is a good product. It outlines several factions (not all, in my opinion, technically "divine" in any form of the word, but I'm griping early), with a fair amount of detail. It also has pretty good artistic arrangement, if the indentation is a mite off.
Good: Art, somewhat creative (in some ways).
Now it's gripe time. All these gripes are pedantric and minor, so don't let them detract too much. However, if these were addressed, the rating would be a five instead of a four.
Affecting the electrical impulses of the brain would not necessarily cause brain bleeds. I'm no expert, but the term "seizures" comes to mind. The brain is fragile, but it won't bleed at random. Seizures and permanent damage is more likely than bleeding.
All the fantasy-oriented factions seem cliche in that setting, some seem out of place in modern settings.
Some of the factions (coughfracturescough), seem to be an embodiment of social upheaval, which is not necessarily something a savvy GM would put in a campaign, since a lot of their players may come from backgrounds in which such situations exist (put two Christians of a different denomination together [or any two religious people with similar but different views], and add in the Fractures as a plot element, and watch the sparks fly).
Also, a lot of the factions would need to be pretty heavily "nerfed" to use a video game term, in order to not pretty much automatically kill the players. Nano-Virus, I'm looking at you.
Pedantry: Nano-Virus isn't technically the right term either.
There. Now that I've got the negative out, I'll apologize. This is a good product, with the exception of the typesetting, which sometimes creates issues. The art is top-notch, and the writing is good. It's worth the money.
[4 of 5 Stars!]