This is a great setting! I really enjoy the amount of detail; enough but not so much that it gets in the way of a good story. In the same vein, the setting rules are different enough to add the needed flavor but are not overwhelming.
The setting focuses on a single star system (important due to the horde activity in the area) but gives enough information about the surrounding planets and systems to run a space traveling campaign. In fact, Nemezis has a flavor all its own but you can easily run any sci-fi trope you like.
The book itself is put together well; the art, writing and organization all lend themselves to a great game.
The only complaint I have is the lack of information regarding cyborgs. The setting mentions them in several locations, prominently in fact, but there are no rules for using them (either as wild cards or enemies). At the least, I would have liked to see a cyborg in the bestiary section. The lack of this information is the only reason I haven’t given Nemezis five stars.
Cyborgs aside, this is a wonderful setting for any type of sci-fi game you might want to run. The flavor is great, the setting information is spot on and the setting rules (gear, new rules, etc.) are perfect.
[4 of 5 Stars!]