I haven't run this yet, and I don't plan to, so perhaps this review isn't of much help.
I've read it pretty much cover-to-cover twice now though and since there aren't any reviews up yet I thought I'd share my impressions.
It's clear a lot of work and thought and talent went into this and it's an amazing product. The art is fantastic, especially the pieces by Matthew Adams. The new races are great. The setting/rules combination works much better than I would have guessed. The greatest thing I think is how well integrated it all is. Everything exists for a purpose, and all the cool stuff ties together really well.
But the reason I won't play is that in a world of simplified games, this one has gone in the opposite direction. There are new attributes two different kinds of hit points, and all the multide of options have multitudes of crunch. For some--many perhaps--this is a feature but for me it feels a lot like doing math. I'd be happy to play this but as a GM (Agonarch) it requires a lot of work. That said, this is probably a "Must-Have" for RPG fans for the sheer wealth of ideas (and again how well they all tie together) as long as they don't mind lots of fiddly bits.