Another in this series of wonderful little settlements all ready to pop into your campaign world, Murderhole has an interesting history that's loose enough to enable you to put it somewhere suitable in whatever setting you are using yet fascinating enough that it will begin to come alive...
It started out like many such a settlement, growing prosperous in a good location with natural resources and a ready trade route. Only squabbling petty lordlings left it unguarded, and as they failed in their duty of care less salubrious folk moved in, and after a series of raids a bunch of bandits have actually based themselves there.
Perhaps your players will oust the bandits. Or join them. Or replace them. Or assume the responsibilty that previous rulers abandoned. Who knows? The adventures are up to you, but here is presented a suitable location in which they can take place.